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© Reuters U.S. stocks lower at close of trade; Dow Jones Industrial Average down 1.07%

Investing.com – U.S. stocks were lower after the close on Wednesday, as losses in the , and sectors led shares lower.

At the close in NYSE, the fell 1.07%, while the index lost 1.94%, and the index declined 3.34%.

The best performers of the session on the were Merck & Company Inc (NYSE:), which rose 2.43% or 1.87 points to trade at 78.88 at the close. Meanwhile, Intel Corporation (NASDAQ:) added 1.37% or 0.73 points to end at 53.87 and Walmart Inc (NYSE:) was up 1.35% or 1.92 points to 143.92 in late trade.

The worst performers of the session were Salesforce.com Inc (NYSE:), which fell 8.28% or 20.56 points to trade at 227.67 at the close. Microsoft Corporation (NASDAQ:) declined 3.84% or 12.63 points to end at 316.38 and Apple Inc (NASDAQ:) was down 2.66% or 4.78 points to 174.92.

The top performers on the S&P 500 were Nucor Corp (NYSE:) which rose 4.83% to 122.72, Merck & Company Inc (NYSE:) which was up 2.43% to settle at 78.88 and AT&T Inc (NYSE:) which gained 2.22% to close at 26.21.

The worst performers were Enphase Energy Inc (NASDAQ:) which was down 11.82% to 157.20 in late trade, Salesforce.com Inc (NYSE:) which lost 8.28% to settle at 227.67 and Paycom Soft (NYSE:) which was down 7.93% to 360.78 at the close.

The top performers on the NASDAQ Composite were Lixte Biotechnology Holdings Inc (NASDAQ:) which rose 63.70% to 2.210, Mainz Biomed BV (NASDAQ:) which was up 46.39% to settle at 15.21 and BTCS Inc (NASDAQ:) which gained 43.89% to close at 4.3600.

The worst performers were Annexon Inc (NASDAQ:) which was down 34.06% to 7.26 in late trade, Applied Therapeutics Inc (NASDAQ:) which lost 23.54% to settle at 4.45 and Monte Rosa Therapeutics Inc (NASDAQ:) which was down 22.62% to 15.63 at the close.

Falling stocks outnumbered advancing ones on the New York Stock Exchange by 2624 to 640 and 124 ended unchanged; on the Nasdaq Stock Exchange, 3033 fell and 823 advanced, while 171 ended unchanged.

Shares in Annexon Inc (NASDAQ:) fell to all time lows; down 34.06% or 3.75 to 7.26. Shares in Mainz Biomed BV (NASDAQ:) rose to all time highs; rising 46.39% or 4.82 to 15.21. Shares in Applied Therapeutics Inc (NASDAQ:) fell to all time lows; losing 23.54% or 1.37 to 4.45. Shares in Monte Rosa Therapeutics Inc (NASDAQ:) fell to all time lows; falling 22.62% or 4.57 to 15.63.

The , which measures the implied volatility of S&P 500 options, was up 16.68% to 19.73.

Gold Futures for February delivery was down 0.23% or 4.10 to $1810.50 a troy ounce. Elsewhere in commodities trading, Crude oil for delivery in February rose 0.30% or 0.23 to hit $77.22 a barrel, while the March Brent oil contract rose 0.11% or 0.09 to trade at $80.22 a barrel.

EUR/USD was unchanged 0.00% to 1.1313, while USD/JPY rose 0.00% to 116.11.

The US Dollar Index Futures was down 0.10% at 96.175.

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